Figure 6. Effects of halothane on intracellular concentration of inositol 1,4,5-triphosphate ([IP3]i) of carbachol-stimulated canine tracheal smooth muscle. (A) Effects of 3.0% halothane on time-dependent changes in the [IP3]iinduced by 10-5M carbachol. (B) Effect of halothane (0.0, 1.0, 2.0, and 3.0%) on the peak [IP3]i10 s after stimulation with carbachol. Symbols represent mean +/- SD (n = 8 at each point). *P < 0.05;**P < 0.01 compared with the control values for the same time course. [dagger] P < 0.05;[dagger, dagger] P < 0.01 compared with the control value without halothane.