Figure 2. Methoxyflurane and isoflurane display additivity. The concentration of methoxyflurane was held at 0.25, 0.50, or 0.75 minimum inhibitory concentration (MIC), and the minimum concentration of isoflurane required to completely inhibit growth for 3 days was determined. At least three independent determinations were made for each combination of agents. Each determination yielded indentical results. For all combinations tested, growth of Zzz⁺yeast was completely inhibited at an additive concentration of 1 MIC. The MIC for methoxyflurane is 0.0137 +/- 0.0003 atm, and the MIC for isoflurane is 0.120 +/- 0.003 atm.