American Society of Anesthesiologists

Figure 3. Tracings showing simultaneous measurement of halothane-induced tension transients and release of Ca2+ from the SR in a skinned pulmonary arterial strip from a simple load-release cycle. Halothane at 1% increased F340(A) and decreased F380(B), thus increasing the F340-to-F380ratio (F340/F380) equivalent to 47.7 nM Ca2+(C), which was followed by a tension transient (D). Ca2+(nM)= calculated Ca2+ in nM; F sub 340 (V)= voltage of fura-2 fluorescence from 340 nm excitation wavelength; F380(V)= voltage of fura-2 fluorescence from 380 nm excitation wavelength.

Figure 3. Tracings showing simultaneous measurement of halothane-induced tension transients and release of Ca²+ from the SR in a skinned pulmonary arterial strip from a simple load-release cycle. Halothane at 1% increased F³⁴⁰(A) and decreased F³⁸⁰(B), thus increasing the F³⁴⁰-to-F³⁸⁰ratio (F³⁴⁰/F³⁸⁰) equivalent to 47.7 nM Ca²+(C), which was followed by a tension transient (D). Ca²+(nM)= calculated Ca²+ in nM; F sub 340 (V)= voltage of fura-2 fluorescence from 340 nm excitation wavelength; F³⁸⁰(V)= voltage of fura-2 fluorescence from 380 nm excitation wavelength.

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