Figure 10. Influence of inhibitors of protein kinase C on the effects of 3% halothane on the submaximum Ca2+-activated force in skinned pulmonary arterial strips. Data are mean +/- SEM (n = 4–7). Force development activated by 1 micro Meter Ca2+ at 1 min (A) and 15 min (B) after administration of halothane is expressed as percent of control force (before administration of halothane). The halothane-induced increases (time control [TC], A) in force were blocked by 10 micro Meter bisindolylmaleimide HCl (Bim, an inhibitor of alpha and epsilon isozymes) but not by 10 micro Meter Go-6976 (Go, an alpha isozyme inhibitor)(A). In contrast, halothane-induced decreases (TC, B) in force were enhanced by Bim but not affected by Go (B). *P < 0.05 compared with TC.