Figure 1. Rats were subjected to bilateral carotid occlusion combined with systemic hypotension for 10 min. Time to depolarization defined as a shift in hippocampal CA1 direct current potential is plotted as a function of pericranial temperature during the ischemic insult. Open circles depict values for single animals. A best-fit line is provided. Time to depolarization increased with decreasing pericranial temperature (P < 0.0001).