Figure 9. The effect of bradykinin on coronary flow and the percentage of oxygen extracted in the absence and presence of isoflurane. Hearts were perfused with canine erythrocytes. Isoflurane alone did not increase coronary flow (P > 0.1) but decreased the percentage of oxygen extraction in a concentration-dependent manner ([bullet] P < 0.05); the bradykinin-induced increase in coronary flow and decreases in the percentage of oxygen extracted (#P < 0.05) were not altered by isoflurane.