Figure 10. Xenon effects on Ca²⁺homeostasis in cortical neurons. Shown are confocal microfluorimetric tracings of the N-methyl-D-aspartate (NMDA) response in a representative cultured mouse embryonic cortical neuron exposed to increasing concentrations of xenon (all less than the minimum alveolar concentration [MAC]). NMDA was applied after 10 min of sequential superfusion with buffers equilibrated with dry gas mixtures of 20% oxygen and xenon-nitrogen in ratios providing xenon partial pressures ranging from 0–80% of 1 atm. Calculated maximum MAC-equivalent values of xenon solutions were 0.20, 0.40, 0.60, and 0.80, as described in the text.