Figure 4. The percentage of dead neurons in the hippocampal formation 72 h after 120 min of hypothermic circulatory arrest. Pretreatment with aptiganel (n = 5) significantly attenuated neuronal necrosis in CA1 and CA3 (*P < 0.05 for aptiganel vs. vehicle). Neuronal necrosis was not observed in the dentate gyrus of either vehicle- or aptiganel-treated animals.