Figure 5. Changes with time in creatinine clearance in the three groups. Individual (open symbols) and mean + standard deviation values (closed symbols) are shown (triangle = low-flow isoflurane, circle = low flow sevoflurane, square = high-flow sevoflurane; n = 14). The dotted line represents the lower limit of the reference range. No abnormal changes in creatinine clearance were noted during the study period. #P < 0.05 compared with each preoperative value.