Figure 7. Changes with time in 24-h urinary [small beta, Greek]2-microglobulinexcretion in the three groups. Individual (open symbols) and mean + standard deviation values (closed symbols) are shown (triangle = low-flow isoflurane, circle = low flow sevoflurane, square = high-flow sevoflurane; n = 14). Note the logarithmic scale used in this graph. The dotted line represents the upper limit of the reference range. Urinary excretion of [small beta, Greek]2-microglobulinin both the low-flow sevoflurane and high-flow sevoflurane groups was significantly greater after anesthesia than before anesthesia. There was no significant difference among the three groups. #P < 0.05, ##P < 0.01 compared with each preoperative value.