Figure 8. Changes with time in 24-h urinary protein excretion in the three groups. Individual (open symbols) and median values (closed symbols) are shown (triangle = low-flow isoflurane, circle = low flow sevoflurane, square = high-flow sevoflurane; n = 14). When the urinary concentration of protein was below the lowest determinable level, the urinary excretion of protein was zero. The number of urine samples below the lowest determinable level is shown. Note the logarithmic scale used in this graph. The dotted line represents the upper limit of the reference range. Urinary excretion of protein in the low-flow sevoflurane group was significantly greater than in the isoflurane and high-flow sevoflurane groups after anesthesia. [dagger] P <0.05, [dagger, dagger] P <0.01 compared with the isoflurane group.fP <0.05,ffP < 0.01 compared with the high-flow sevoflurane group. #P <0.05 compared with each preoperative value.