Figure 4. Effects of various concentrates of isoflurane on myosin light chain phosphorylation (MLC-p) during isoflurane-induced increases in force development. Means +/- SD (n = 6-21); MLC-p expressed as a percentage of total MLC. *P < 0.05 compared with that of time controls (0% isoflurane); isoflurane (1-3%) dose dependently decreased MLC-p and was significant at 3% isoflurane.