Figure 1. Propofol-induced anterograde and retrograde amnesia of a passive avoidance response in the rat. The effects of propofol, administered 15 min before training or 3 h after training, on recall at the 12 h post-training time are illustrated. Latencies represent the median and interquartile range (n = 6) and those significantly different (P < 0.05; Mann-Whitney U-test) from control animals (open columns) are indicated by an asterisk.