Figure 2. Coronary collateral and left circumflex coronary artery (LCCA) blood flow (expressed as percent of baseline) in dogs receiving vehicle (VEH) or glyburide (GLB) in the presence or absence of sevoflurane (SEV). Sevoflurane increased large collateral (retrograde)(A) and small collateral (tissue) blood flow (B) in the presence of glyburide. (C) Sevoflurane did not alter LCCA blood flow. These findings demonstrate that sevoflurane selectively dilates coronary collaterals independent of K^ATPchannel activation. * Significantly (P < 0.05) different from baseline;[Section] significantly (P < 0.05) different from vehicle alone;[paragraph mark] significantly (P < 0.05) different from glyburide alone.