![Figure 4. Interval mapping of QTL location for chromosome V. The likelihood ratio (LR) represents a statistical measure of association between anesthesia phenotypes in the RIs and chromosomal location. [27,30]LR = 2 log(L1/L0) where L1/L0is the odds ratio that a quantitative trait locus (QTL) is present at that location and is plotted against the center and right segment of chromosome V. As shown previously, the genetic distance in map units (mu) between markers in these RIs is expanded two times more than the standard C. elegans map derived from single recombination frequencies. [13]The QTL significance levels were set at P < 0.05 (dotted line) and were determined by 999 permutations of the phenotypes against the genotypes. [13,31]](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/89/6/10.1097_00000542-199812000-00030/2/30ff4.png?Expires=1716435769&Signature=K3JYlUz7vcfRWti~44Uitc3dCYWsVR4oIVb1nn2jToRTSnRjGPwnT0IWhZh3TqzD6bD3Pc86a4D~BAwa7k92hTks6gRi5r3CxO1PFJZ1zkC-PjpoxoL0eMSUpfJQR8AGAk7ZqhW~RA3HC-jJGcVNc1OWBhgVMUy08XPI9m7dWIBUWGrJu7XOjMQ8EozVzCbYmluo4QP7NxuwB-dbFLK4rDp-L8Bs3kPGID2M8MZWbiZBBm1fXDXNBw3LJGpztgAQNLgzYchVs7AZrn~CHjZxEpilX36UlG1o~Mjh9j-GonOMxIB23pZi0lT8oM0icDGE49KRWDV65EuXkTOgrfp0dA__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 4. Interval mapping of QTL location for chromosome V. The likelihood ratio (LR) represents a statistical measure of association between anesthesia phenotypes in the RIs and chromosomal location. [27,30]LR = 2 log(L1/L0) where L1/L0is the odds ratio that a quantitative trait locus (QTL) is present at that location and is plotted against the center and right segment of chromosome V. As shown previously, the genetic distance in map units (mu) between markers in these RIs is expanded two times more than the standard C. elegans map derived from single recombination frequencies. [13]The QTL significance levels were set at P < 0.05 (dotted line) and were determined by 999 permutations of the phenotypes against the genotypes. [13,31]
