Figure 6. The effects of volatile anesthetics on miniature inhibitory postsynaptic current (mIPSC) decay time. (A) Normalized mIPSCs in response to three concentrations of enflurane (left) and isoflurane (right). Enflurane and isoflurane prolong mIPSCs to a similar extent. Values for [small tau, Greek]wt, expressed in milliseconds, are given in the following Table 1. (B) Concentration dependence of volatile anesthetic effects on the mIPSC-weighted decay time constant. Data are normalized to control values and plotted versus the aqueous anesthetic concentration. (C) The concentration dependence of volatile anesthetic effects on the mIPSC-weighted decay time constant, as shown in panel B, but data are plotted versus the MACAqfraction (see the legend to Figure 3). The numbers of cells for each data point in panels B and C are the same as in Figure 3. Squares = enflurane, circles = isoflurane, triangles = halothane. Dashed lines are Hill Equation fitsto the data.