Figure 8. Simulation of administration of acetaminophen. A loading dose of 40 mg/kg administered orally preoperatively, supplemented by a 20-mg/kg suppository 2 h later. Parameter estimates, standardized to a 70-kg person, are V/Foral= 60 1/70 kg, CL/Foral= 13.5 l [middle dot] h-1[middle dot] 70 kg-1, and Tabs= 4.5 min for the oral elixir and T (abs)= 35 min with a lag time of 40 min for the suppository. The Frectal/oralvalue was 0.54. Variability is shown using bax-and-whisker plots. The central box represents the fiftieth percentile. Indentations in this box indicate the median. Values outside the 97.5% percentile are shown individually.