Figure 8. Computer simulations of Figure 11using the parameters in Table 3. (A) The relative concentrations of receptors in the unliganded resting (R), singly liganded resting (AR), doubly liganded preopen (A²R), open (A²R*), and desensitized (A²D) states after exposure to 1 mM acetycholine (no isoflurane). (B) The relative concentrations of receptors in the unblocked, open (A²R*) state on exposure to 1 mM acetylcholine after preincubation with the indicated concentrations of isoflurane. This concentration approximates that achieved at the neuromuscular junction at the time of nicotinic acetylcholine receptor activation. (C) The relative concentrations of receptors in the unblocked, open (A²R*) state on exposure to 1 [micro sign]M acetylcholine after preincubation with the indicated concentrations of isoflurane. The y axis used in C is much smaller than that used in B.