![Figure 1. Dose-response relationship of N2O analgesic effect in wild-type and [small alpha, Greek]2Atransgenic mice. Different groups of mice (n = 8 per group) were exposed for 30 min to N2O (25%, 50%, and 75%) or to air in an enclosed chamber. Tail-flick latency was then measured. Data are expressed as mean +/− SEM. *= significantly different (P < 0.05) from baseline measurement. When the two groups of mice are analyzed by two-way analysis of variance, the antinociceptive response curves are statistically significantly different. P < 0.0001.](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/90/2/10.1097_00000542-199902000-00022/2/22ff1.png?Expires=1716617564&Signature=iF9A~hr-k~OoArAb2V9cqfiv6~2g4UYjokDIIYXpO2zHRC-UwabMxfjhJTysogW697kZQ7hIzaPaWyELbqyHIwXx~85fQJb0C63Sqy6OpV5wcDNXNN2ftAc7ZGHdiiiuhoALqVzuAK-eSwVunARbiRxIeLwOeSRbaLRW-0-xEcp83wWdCU5W~gGYUwHO~t-KIuDUmrL6TkO85441LZpCWRl6Og1gW8huyBOF~79fomAYcyi3ljEB5pSwOvzaJ6eRYQBtzFYTT~9~A0JRwYIutPESl4SvTjSTG~uT7LkjIAxejnzSu-2Hl3IwXomtNDku9P4YGOzRRPGPbz5OwxxkNw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 1. Dose-response relationship of N2O analgesic effect in wild-type and [small alpha, Greek]2Atransgenic mice. Different groups of mice (n = 8 per group) were exposed for 30 min to N2O (25%, 50%, and 75%) or to air in an enclosed chamber. Tail-flick latency was then measured. Data are expressed as mean +/− SEM. *= significantly different (P < 0.05) from baseline measurement. When the two groups of mice are analyzed by two-way analysis of variance, the antinociceptive response curves are statistically significantly different. P < 0.0001.
