Figure 2. Composite left pulmonary vascular pressure-flow (LPQ) plots in seven dogs at baseline, after preconstriction with U46619, and during administration of lemakalim (1 [micro sign]g [middle dot] kg^-1[middle dot] min^-1given intravenously) in the conscious state (upper) and during isoflurane anesthesia (lower). Composite LPQ plots were generated using the regression parameters from each continuously measured LPQ plot, as described in Materials and Methods. In the conscious state and during isoflurane anesthesia, this dose of lemakalim caused a rightward shift in the LPQ relation, indicating pulmonary vasodilation (*P < 0.05).