Figure 5. Composite left pulmonary vascular pressure-flow (LPQ) plots measured in eight dogs in the conscious state (A) and on a separate day during isoflurane anesthesia (B) in the intact condition and after pretreatment with glibenclamide. Composite LPQ plots were generated using the regression parameters from each continuously measured LPQ plot, as described in Materials and Methods. Glibenclamide had no effect on the LPQ relation in either conscious or isoflurane-anesthetized dogs.