Fig. 7. (  A ) Composite left pulmonary vascular pressure–flow (LPQ) plots in six conscious dogs during normoxia and hypoxia with or without pretreatment with glibenclamide (GLIB). Glibenclamide had no effect on the LPQ relationship during normoxia compared with the no-drug condition. Hypoxia caused a leftward shift (*  P < 0.01) in the LPQ relationship following glibenclamide. (  B ) Composite hypoxic pulmonary vasoconstriction (HPV) response as a function of left pulmonary flow in the conscious state in the no-drug condition and following gilbenclamide. The HPV response was potentiated (*  P < 0.01) following glibenclamide compared to the no-drug condition.