![Figure 1. Concentration-response curves to cromakalim (10-7to 3 x 10 (-5) M) and pinacidil (10-7to 3 x 10-5M) in the absence and the presence of glibenclamide (5 x 10-6M), obtained in rat thoracic aortas without endothelia. Data are shown as the mean +/− SD and expressed as percent of maximal relaxation induced by papaverine (3 x 10-4M; 100%= 753 +/− 169 mg [n = 6] and 887 +/− 114 mg [n = 6] for control rings of cromakalim and rings treated with glibenclamide; 100%= 840 +/− 215 mg [n = 5] and 800 +/− 198 mg [n = 5] for control rings of pinacidil and rings treated with glibenclamide, respectively). *Difference between control rings and rings treated with glibenclamide is statistically significant (P < 0.05).](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/90/4/10.1097_00000542-199904000-00032/2/32ff1.png?Expires=1716526927&Signature=cyzKYZ22MWcf90WLFzUouAA7pKqI6qmIucN-WB0B8UYfIs4ns4mPdVEa1XYvQR8zlWIhNooEJ5FRxDFodZp5dLTZp1W9maw9DjqM25TPJVXW6Fi2lrpttMBSpKPVTN3C8hiFBol2Rp6L7jBeA34Xct90772v5EgV79p-wSDR2fbvLX-RneTQvM7saaB9xcxxAoHk7Fx9L~pbQLNDDWhOHr4Hrmu-yAnNcsOsRcRYBsVFi93mkWquWo1~F78m0dwft3L~2dnKatji-rZqvAvJ8MY2Pn4ZfxNym1n8Vtysirp0GDdhHbVP8mpMuloddiHWDdA1ThShKBEcdc0sTCMiHw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Figure 1. Concentration-response curves to cromakalim (10-7to 3 x 10 (-5) M) and pinacidil (10-7to 3 x 10-5M) in the absence and the presence of glibenclamide (5 x 10-6M), obtained in rat thoracic aortas without endothelia. Data are shown as the mean +/− SD and expressed as percent of maximal relaxation induced by papaverine (3 x 10-4M; 100%= 753 +/− 169 mg [n = 6] and 887 +/− 114 mg [n = 6] for control rings of cromakalim and rings treated with glibenclamide; 100%= 840 +/− 215 mg [n = 5] and 800 +/− 198 mg [n = 5] for control rings of pinacidil and rings treated with glibenclamide, respectively). *Difference between control rings and rings treated with glibenclamide is statistically significant (P < 0.05).
