Figure 6. (A) Dissociated dorsal root ganglion cells removed 2 weeks after transection of the sciatic nerve have a significant increase in neurite outgrowth compared with dorsal root ganglion cells taken from healthy animals (*P < 0.005 by the Student t test; n = 4). Inhibition of axonal transport in the sciatic nerve by topical application of vinblastine also induced a significant increase in neurite outgrowth of the dissociated dorsal root ganglion cells compared with untreated controls (50 [micro sign]M; P < 0.005, n = 4). Topical application of the vehicle, saline (n = 4), had no effect on neurite outgrowth. (B) Behavioral experiments show that topical application of vinblastine (n = 4) induces a significant decrease in the mechanical threshold compared with saline-treated control rats (n = 4)(P < 0.0005 by two-way analysis of variance). The results are calculated as:(threshold of treated paw)-(threshold of untreated paw)/(threshold of untreated paw) x 100. (Reproduced with permission from White et al. [ 20 ])