Fig. 3. Relationship between compound A dose, and exposure to compound A ( A ) or sevoflurane ( B ). Compound A dose was estimated from pulmonary uptake and exposure from the area under the curve of inspired compound A concentration versus time (AUCinsp). Sevoflurane exposure was determined from end-tidal MAC-h. Each data point represents one patient. The patient with the highest compound A exposure underwent head-up laparoscopic cholecystectomy with intraabdominal CO2insufflation. The high measured tidal volumes (8–11 l/min, uncorrected for circuit compliance) likely overestimated effective alveolar ventilation, 29 thereby overestimating compound A dose. Correlations without data from this patient are shown by the dotted line (r2= 0.92 for compound A exposure; r2= 0.77 for sevoflurane exposure).