Fig. 5. The pulmonary vasodilator response to 4 ppm inhaled nitric oxide (NO) and perfusion with 2 and 20 mM 8-pCPT-cGMP in lipopolysaccharide-pretreated (closed bars) and control (open bars) wild-type mice ( A ) and NOS2-deficient mice ( B ). Vasodilatation in response to inhaled NO (iNO), and to 8-pCPT-cGMP, was impaired in lipopolysaccharide-pretreated wild-type mice compared with control wild-type mice (* P < 0.05 vs. control) but was not different between lipopolysaccharide-pretreated and control NOS2-deficient mice. Data are expressed as the mean ± SE.