Fig. 1. Time course of effect at the adductor pollicis is shown for the same individual displayed in figure 3 in the study by Wright et al. 1,The solid line displays the time course after a bolus rapacuronium dose of 1.5 mg/kg. The dotted line displays the time course predicted for the same bolus dose, assuming that k eois 2.4 times smaller, i.e. , a value similar to that for rocuronium 1 ; note that peak effect is less and recovery longer than with the larger k eo. The dashed line displays the predicted time course for a bolus dose (2.3 mg/kg) that yields that same peak effect-site concentration as the solid line, assuming the smaller k eo; note that recovery is yet longer. Therefore, a larger k eo(more rapid equilibration between plasma and effect site) speeds both onset and recovery.