Fig. 7. Changes in concentrations of (A ) epinephrine (Epi) and (B ) norepinephrine (NE) in plasma before and after rapid intravenous administration of bupivacaine (2 mg/kg) in conscious rats. Bupivacaine was injected at time 0. Values represent mean ± SD in three rats. At 30 s, the increase in blood pressure was maximal. At 1.5 min, baroreflex was depressed.