Fig. 2. Effects of halothane on verapamil-resistant influx of Ca²⁺estimated by measurement of influx of ⁴⁵Ca²⁺. (A ) Time course of influx of Ca²⁺. Means ± SDs are shown. Note that strips were exposed to ⁴⁵Ca²⁺only for the last 2 min before the time indicated in each data point. Stimulation with phenylephrine 300 nM for 10 min induced significantly larger influx of Ca²⁺than at 0 min (#P < 0.05). Halothane 1% and 4%, introduced at this time, further enhanced influx of Ca²⁺(*P < 0.05 compared with 0%). n = 10 in each group. (B ) Effects of varied concentrations of halothane (circle) and sevoflurane (square) on influx of Ca²⁺10 min after introduction (20 min after phenylephrine). Means ± SDs are shown. Halothane 1% and 2% induced significantly larger influx of Ca²⁺compared with 0% (*P < 0.05). n = 10 in each group.