Fig. 3. (Lower ) The coefficient of variation of γ estimates. (Upper ) The percentage of simulations in which the 95% confidence intervals contained the true value of γ. For these simulations, the initial values of drug concentration associated with a 50% probability of drug effect (C50) and γ were 100 and 1.0 times the true value, respectively, and it was assumed that data came from a single patient. The different curves present results for γ= 1.0 (•-•), 1.5 (▪-▪), 3.0 (x-x), 4.5 (♦-♦), and 6.0 (▴-▴).