Fig. 4. (Lower ) The coefficient of variation of C⁵⁰estimates. (Upper ) The percentage of simulations in which the 95% confidence intervals contained the typical value of C⁵⁰. For these simulations, the initial values of C⁵⁰and steepness of the concentration-effect relation (γ) were 100 and 1.0 times the typical value, respectively, and it was assumed that data from multiple patients was pooled and that C⁵⁰and γ had log-normal distributions, with SDs of log C⁵⁰and log γ equal to 30% of the typical values. The typical value of C⁵⁰was 100. The different curves present results for γ^TV= 1.0 (•-•), 1.5 (▪-▪), 3.0 (x-x), 4.5 (♦-♦), and 6.0 (▴-▴).