Fig. 5. (Lower ) The coefficient of variation of γ estimates. (Upper ) The percentage of simulations in which the 95% confidence intervals contained the typical value of γ. For these simulations, the initial values of drug concentration associated with a 50% probability of drug effect (C50) and γ were 100 and 1.0 times the typical value, respectively, and it was assumed that data from multiple patients was pooled and that C50and γ had log-normal distributions with SDs of log C50and log γ equal to 30% of the typical values. The typical value of C50was 100. The different curves present results for γTV= 1.0 (•-•), 1.5 (▪-▪), 3.0 (x-x), 4.5 (♦-♦), and 6.0 (▴-▴).