Fig. 2. Effects of propofol (PPF) or HOE 642 alone or in combination on left ventricular developed pressure and left ventricular end-diastolic pressure (EDP) during reperfusion after 60 min of global ischemia in rat hearts. Drugs were present for 15 min before ischemia and throughout the reperfusion period. Values are mean ± SD and n = 6 for all groups. (  Top ) Values depict percentage of preischemic values (BL3 in  table 1 ). Values for HOE 642 alone were significantly greater than for controls at all times during reperfusion and from propofol alone for the first 15 min. Values for the propofol-alone group were significantly higher than those for controls from 10 min until the end of reperfusion. Values for the combination of PPF and HOE 642 were greater than those for all other groups for the final 5 min of reperfusion. *  P < 0.05 compared with all other groups. (  Bottom ) The EDP was set at 5 mmHg before ischemia. Values depict the recorded EDP. Values for HOE 642, PPF, and PPF plus HOE 642 are significantly less than those for controls during the entire reperfusion. For the first 10 min, the groups that received HOE 642 had significantly less increase in EDP than did the PPF group. *  P < 0.05 compared with all other groups.