Fig. 5. Effects of sevoflurane (SEVO) or glyburide (GLYB) alone or in combination on left ventricular developed pressure and left ventricular end-diastolic pressure (EDP) during reperfusion after 60 min of global ischemia in rat hearts. Drugs were present for 15 min before ischemia and throughout the reperfusion period. Values are mean ± SD and n = 6 for all groups. (  Top ) Values depict percentage of preischemic values (BL3 in  table 1 ). Values for the SEVO-alone group were significantly higher than those for controls from 15 min until the end of reperfusion. Values for the GLYB group were not significantly different from those for controls over the whole reperfusion period. Values for the combination of SEVO and GLYB were significantly less than those for the SEVO group for the final 25 min of reperfusion and were not statistically different from those for controls or the GLYB group over this period. *  P < 0.05 compared with controls. **  P < 0.05 compared with all other groups. (  Bottom ) The EDP was set at 5 mmHg before ischemia. Values depict the recorded EDP. Only values for the SEVO group were significantly less than those for controls during the entire reperfusion period. *  P < 0.05 compared with controls.