![Fig. 7. Concentration–response curves to sodium nitroprusside in the absence or in the presence of ODQ (5 × 10−6M) or mexiletine (3 × 10−5M) obtained in rat thoracic aortas without endothelia. Data are shown as the mean ± SEM and expressed as percent of maximal relaxation induced by papaverine (3 × 10−4M; 100%= 816 ± 102 mg [n = 5], 824 ± 61 mg [n = 5], and 760 ± 18 mg [n = 5] for control rings, rings treated with ODQ, or rings treated with ODQ plus mexiletine (3 × 10−5M), respectively). *Difference between control rings and rings treated with ODQ and #difference between rings treated with ODQ and rings treated with ODQ plus mexiletine, are statistically significant, respectively (P < 0.05).](https://asa2.silverchair-cdn.com/asa2/content_public/journal/anesthesiology/92/3/10.1097_00000542-200003000-00025/2/25ff7.png?Expires=1716631414&Signature=P5DNYS8JVs4J01zgkyh5pO60YhHRQyKAvJGHmvmYaAfMI~ZNigzCHVYN4iDasX857GFdAFKzUr6u12GI3O9L6myjqxS1O6uq-qmSzXj5TCRIAPxmHnZ4t80TOV9ewsz7RAm752db85LnGcduaQqfSHVWvu3rLzOSp1v4iEyZdWHiY2TTNrtq4ShfKRbCtPbMwsfu7VfrYKpM0m9LDXfgHZUKJmVyb4Ykoa~QuKZn9CZth5AxZ1gDG7ANiMgyMq42S8zcEbAxzFTiIM880ur0bweQd8OiqXAWSJbOJUZfNCLqfmGbCARCg36lBMF7NTNGGmIBIhYZruBCP30uKXw7sw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Fig. 7. Concentration–response curves to sodium nitroprusside in the absence or in the presence of ODQ (5 × 10−6M) or mexiletine (3 × 10−5M) obtained in rat thoracic aortas without endothelia. Data are shown as the mean ± SEM and expressed as percent of maximal relaxation induced by papaverine (3 × 10−4M; 100%= 816 ± 102 mg [n = 5], 824 ± 61 mg [n = 5], and 760 ± 18 mg [n = 5] for control rings, rings treated with ODQ, or rings treated with ODQ plus mexiletine (3 × 10−5M), respectively). *Difference between control rings and rings treated with ODQ and #difference between rings treated with ODQ and rings treated with ODQ plus mexiletine, are statistically significant, respectively (P < 0.05).
