Table 2. Effect of Isoflurane on Immunostimulated Nitrite Production in the Presence and Absence of Ionomycin

Nitrite concentration (μM) in the culture supernatant of J774 macrophages 18 h after immunostimulation and incubation with and without 2 MAC isoflurane in the absence or presence of ionomycin (1 μM). Data are presented as mean ± SD of four separate experiments performed in duplicate.

LPS = lipopolysaccharide; γIFN = interferon gamma.

* Significant (P < 0.05) vs.  control group without ionomycin.

† Significant vs.  anesthetic control without ionomycin.

‡ Significant vs.  2 MAC isoflurane without ionomycin.