Fig. 5. Predicted arterial and effect-site concentrations after administration of 1 mg morphine by either the intravenous or the inhalation route. The curves depicting the arterial plasma concentrations use the kinetic parameters from table 1. The curves depicting the effect-site concentrations are obtained by convolution of the arterial plasma concentration curves, with a curve of the form y = k^e0e^−ke0tusing the E^maxpharmacodynamic parameters from table 4. The model predicts that similar effect-site concentrations would be achieved after administration of 1.0 and 1.7 mg morphine intravenously and via  the AERx device, respectively.