Fig. 4. Fifty percent response thresholds to von Frey filaments in diabetic rats after repeated injections of 1 mg/kg TX14(A) (filled circles). Animals that received equivalent injections of TX14(A) but were only tested after the final injection are shown by open squares. Data are median ± 95% confidence limits. n = 6 per group. *P < 0.02 versus  the repeatedly tested group at this time point by Mann–Whitney U test for nonparametric data.