Fig. 5. Measured (dashed lines) and covariate (shed blood volume) adjusted population model estimates (solid lines) of remifentanil blood levels for the control group (A ) and the shock group (B ). (C ) The measured over predicted plot for the shed blood volume adjusted population model using all animals from both the control and shock groups. Each line represents the performance of the shed blood volume adjusted population model when applied to an individual pig. A pig whose blood concentrations were perfectly predicted by the model would be represented by a straight line at 1. Solid lines represent shock animals, and dashed lines represent control animals.