Figure 1. (Left) Figure displaystime-dependent changes in arousal (top), muscle tone (middle), and coordination (bottom) after epidural injection of lipid vehicle (blank DepoFoam); 5 mg/3 ml morphine in saline; 10 mg/3 ml C0401; or 30 mg/3 ml C0401. Behavioral scores are presented as the mean of five animals at each treatment. (Right) Histograms show the areas under the curve (mean +/- SEM) for effects on the respective endpoints produced by the several epidural treatments. The ordering of the peak depression of arousal, coordination, and muscle tone was 30 mg/3 ml C0401 = 10 mg/3 ml C0401 = 5 mg/3 ml morphine in saline > blank = 0 (one-way analysis of variance, P < 0.05 and post hoc Bonferroni tests). The ordering of the duration of these changes, as defined by the area under the curve for all indices, was 30 mg/3 ml C0401 > 10 mg/3 ml C0401 = 5 mg/3 ml morphine and saline > blank = 0 (one-way analysis of variance, P < 0.05 and post hoc Bonferroni tests).