Figure 6. The effects of halothane and isoflurane on the recovery from inactivation. Standard two-pulse protocols were used to measure the recovery from (A) fast and (B) slow inactivation (see Materials and Methods). The normalized current was plotted versus the recovery interval. Solid lines are single exponential fits giving the time constant [Greek small letter tau] of recovery. (A) Recovery from fast inactivation is shown. The time constant was significantly increased by 1.1 mM halothane, but not by 1 mM isoflurane. Data are the mean +/- SEM (n ranged from 10 cells to 15 cells). (B) Recovery from slow inactivation is shown. The time constant of the recovery from slow inactivation was not affected by halothane and isoflurane. Data are the mean +/- SEM (n = 4 in each group).