Fig. 1. Data used to validate the predicted carboxyhemoglobin (COHb) concentrations. These data show a good fit to the experimental data of Frink et al.  5(n = 10; r²= 0.961; mean difference between calculated and experimental carboxyhemoglobin = 2.2%). For the exposure reported by Berry et al. , 12this model predicted carboxyhemoglobin concentration within 2% of the measured value (n = 1) but also predicted a peak carboxyhemoglobin concentration of 42% before interventions to stop and treat the exposure.