Figure 9. The sleep duration after the bolus dose was calculated using the age-adjusted pharmacokinetic model for all participants. The upper panel shows the results with the population mean C⁵⁰for all volunteers from the loss-of-consciousness analysis. The lower panel shows the results with the C⁵⁰adjusted for age. The age correction produced a modest decrease in bias and improvement in accuracy in predicted sleep duration. The straight line indicates unity.