Fig. 2. Box plots of the coefficient of determination, R², and the median performance error of the fits during the initial infusion and the combined subsequent infusions, with use of nonparametric (NP) and parametric (P) modeling for electroencephalographic data analyzed with aperiodic analysis (Amp) and bispectral analysis (BIS). The boxes represent the median, 25th–75th percentiles, and range, including extremes ().