Fig. 3. (Top ) Area of hyperalgesia to punctate mechanical stimulation (closed circles) and area of allodynia to light brush (open circles) after the first capsaicin injection, before intrathecal drug injection. Each symbol represents the mean ± SE of 40 volunteers. (Bottom ) Percent reduction in area of hyperalgesia and allodynia to capsaicin injection after intrathecal drug treatment with saline (open bars) or adenosine, 2 mg (filled bars). *P < 0.05 compared with saline.