Fig. 1. Collagen-induced thrombus formation (CITF) is prolonged in patients who require hemostatic transfusion for post-cardiopulmonary bypass coagulopathy. (A ) Blood was drawn at the indicated time points for CITF. Data were analyzed by two-way analysis of variance grouped according to hemostatic transfusion. Data were significantly different for main effects of group (P < 0.001), time (P < 0.001), and group–time interaction (P < 0.005). *P < 0.01 versus before induction of anesthesia; **P < 0.005 versus before induction of anesthesia, intensive care unit arrival, and 4 h after intensive care unit arrival; +P < 0.01 for hemostatic transfusion versus no hemostatic transfusion by Bonferroni-corrected post hoc test. (B ) Box plot analysis of CITF values after protamine administration grouped by hemostatic transfusion. Plots indicate median, 25–75 percentiles, and 95% confidence intervals. Open circles indicate individual values outside the 95% confidence interval. Hemostatic tx = intraoperative platelet or fresh frozen platelet transfusion; Preind = before induction of anesthesia; Post Protamine = 5 min after protamine administration; ICU arrival = on arrival to the intensive care unit; 4H ICU = 4 h after arrival in the intensive care unit.