Fig. 7. (Top ) Representative trace depicting the effect of bisindolylmaleimide (Bis; 1 μm) alone and in combination with propofol (Prop; 100 μm) on capacitative Ca2+entry. After depletion of sarcoplasmic reticulum Ca2+stores with thapsigargin, capacitative Ca2+entry was compared in the absence or presence of bisindolylmaleimide and bisindolylmaleimide plus propofol, which were each added to the superfusion buffer 5 min before restoring extracellular Ca2+concentration ([Ca2+]o). (Bottom ) Summarized data showing that bisindolylmaleimide alone potentiated (*P < 0.05) capacitative Ca2+entry. In the presence of bisindolylmaleimide, propofol no longer had an inhibitory effect on capacitative Ca2+entry (n = 7 cells).