Fig. 2. Influence of α²-adrenoceptor agonists on ibotenate-induced lesions. 2After cresyl violet staining, cortical and white-matter lesions were quantified by counting the number of 15-μm coronal sections with lesions. The bars represent the mean length of the lesions along the sagittal frontooccipital axis ± SD. The numbers in parentheses are the numbers of animals used in each experimental group. Treatment conditions: (A ) dexmedetomidine (0, 1, 3, 10, 30 μg/kg) and (B ) clonidine (0, 4, 10, 40, 400 μg/kg). Y = yohimbine 5 mg/kg. Statistically significant differences between controls and experimental animals are shown:**P < 0.01 and *P < 0.05 versus  control (saline) by analysis of variance followed by Dunnett multiple comparison of means test.