Fig. 1. Plasma antithrombin III (AT) activity concentrations after administration of recombinant human AT (rh-AT) using single doses of 0, 10, 25, 50, 75, 100, 125, 150, 175, and 200 U/kg during cardiac surgery with cardiopulmonary bypass (CPB). rh-AT was administered after intubation. Specimen collection times: Baseline = preadministration, 1 min after rh-AT injection, 5 min after heparin, every 30 min during CPB, before protamine, 10 min and 2, 4, 6, 12, and 24 h after CPB, and protamine reversal. Data are expressed as mean ± SE.