Fig. 3. Relation between D-dimer as markers of activation of coagulation (fibrin formation) and increased and recombinant human antithrombin III (rh-AT). (Top ) The relation between individual plasma concentrations of D-dimer and rh-AT during several cardiopulmonary bypass time points is shown; a significant inverse relation was observed between D-dimer concentrations and rh-AT (D-dimer =−5.7 rh-AT + 1,749, r =−0.49, P = 0.001). (Bottom ) Mean D-dimer values for each dosing cohort are shown. The total number of specimens collected at 15-min intervals during CPB used for analyses was 124. *P < 0.05 compared with placebo patients.

Fig. 3. Relation between D-dimer as markers of activation of coagulation (fibrin formation) and increased and recombinant human antithrombin III (rh-AT). (Top ) The relation between individual plasma concentrations of D-dimer and rh-AT during several cardiopulmonary bypass time points is shown; a significant inverse relation was observed between D-dimer concentrations and rh-AT (D-dimer =−5.7 rh-AT + 1,749, r =−0.49, P = 0.001). (Bottom ) Mean D-dimer values for each dosing cohort are shown. The total number of specimens collected at 15-min intervals during CPB used for analyses was 124. *P < 0.05 compared with placebo patients.

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